Inactivated virus vaccines from chemistry to prophylaxis: merits, risks and challenges
نویسندگان
چکیده
منابع مشابه
Whole-inactivated SARS-CoV-2 vaccines: from fear to hope
Undoubtedly, vaccination can be one of the promising approaches to control infectious diseases such as the COVID-19 pandemic. Inactivated viral vaccines have a history of "vaccine-induced enhanced disease", which may occur when neutralizing antibodies bind to viral antigens without blocking or clearing the infection. This can cause additional inflammation through the mechanisms described for ot...
متن کاملGamma globulin prophylaxis; inactivated rubella virus; production and biologics control of live attenuated rubella virus vaccines.
DR. R. LUNDSTROM, ESKILSTUNA, SWEDEN: The Maternity Welfare Centers in Sweden provide women without a known history of rubella and pregnant up to 14 weeks with convalescent y-globulin, or, when this is not available, ordinary yglobulin as a prophylactic after exposure to rubella cases. Some women have been treated in spite of appearing with manifest rubella. This is, according to earlier experi...
متن کاملImprovement of inactivated influenza virus vaccines.
Inactivated influenza virus vaccines (IVVs) are used for prevention of influenza and its complications. Present vaccines are immunogenic, of low reactogenicity, and protective, but protection has varied between 0% and 100%. Increasing the dose of hemagglutinin and neuraminidase antigens with purified proteins significantly increased serum and nasal antibody responses; however, trials with newer...
متن کاملInactivated influenza virus vaccines in children.
Healthy children aged < or =2 years have hospitalization rates during influenza periods 12 times those of older children and comparable to rates in the elderly population. In 2003, killed influenza vaccines were "recommended" for children with high-risk conditions and were "encouraged" for children aged 6-23 months. Studies involving several thousand children show that split-virus vaccines are ...
متن کاملInactivated Viral Vaccines
The first report of “virus” inactivation for vaccine purposes was described in 1886 when Daniel Elmer Salmon and Theobald Smith immunized pigeons with what they thought was a heat-killed hog cholera “virus” (Salmon and Smith 1886). Although in reality it was a cholera-like bacterium, it seeded the scientific community with evidence that immunization with inactivated pathogens can provide protec...
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ژورنال
عنوان ژورنال: Expert Review of Vaccines
سال: 2012
ISSN: 1476-0584,1744-8395
DOI: 10.1586/erv.12.38